Youfeng Yang Selected Research

Leiomyomatosis

1/2021	Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer.
1/2020	Heterogeneous adaptation of cysteine reactivity to a covalent oncometabolite.
1/2020	Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway.
12/2019	Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc.
1/2013	Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma.
7/2012	A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer.
9/2011	The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.
10/2010	Increasing reactive oxygen species as a therapeutic approach to treat hereditary leiomyomatosis and renal cell carcinoma.
1/2010	UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Youfeng Yang Research Topics

Disease

23	Neoplasms (Cancer) 04/2023 - 02/2002
17	Renal Cell Carcinoma (Grawitz Tumor) 04/2023 - 01/2010
11	Kidney Neoplasms (Kidney Cancer) 01/2021 - 08/2009
9	Leiomyomatosis 01/2021 - 01/2010
5	Carcinogenesis 01/2020 - 05/2006
3	Vascular Calcification 01/2023 - 10/2017
3	Hypoxia (Hypoxemia) 11/2012 - 08/2009
2	Hereditary leiomyomatosis and renal cell cancer 12/2016 - 08/2009
2	Atherosclerosis 06/2016 - 01/2013
1	Disease Progression 01/2021
1	Neoplasm Metastasis (Metastasis) 01/2021
1	Hereditary Neoplastic Syndromes (Cancer Syndrome, Hereditary) 01/2020
1	Starvation 09/2019
1	Vascular Diseases (Vascular Disease) 10/2017
1	Cardiovascular Diseases (Cardiovascular Disease) 10/2017
1	Stroke (Strokes) 10/2017
1	Hypertension (High Blood Pressure) 10/2017
1	Pancreatic Neoplasms (Pancreatic Cancer) 02/2015
1	Retinoblastoma (Glioblastoma, Retinal) 08/2014
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 05/2013
1	Fibrosis (Cirrhosis) 05/2013
1	Ischemia 01/2013
1	Acquired Immunodeficiency Syndrome (AIDS) 07/2012
1	Genetic Translocation (Chromosomal Translocation) 05/2012
1	Iron Deficiencies 09/2011
1	Sleep Wake Disorders 04/2011
1	Neuroblastoma 04/2011
1	Infertility (Sterility) 12/2010
1	Alveolar Soft Part Sarcoma 06/2010

Drug/Important Bio-Agent (IBA)

12	Fumarate Hydratase (Fumarase)IBA 01/2021 - 08/2009
9	EnzymesIBA 01/2021 - 08/2009
6	Proteins (Proteins, Gene)FDA Link 01/2023 - 05/2006
4	Transcription Factors (Transcription Factor)IBA 01/2023 - 05/2006
4	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 08/2009
3	FumaratesIBA 01/2021 - 12/2014
2	Sirolimus (Rapamycin)FDA Link 04/2023 - 09/2019
2	LigandsIBA 01/2021 - 06/2008
2	Mechanistic Target of Rapamycin Complex 1IBA 09/2019 - 08/2014
2	Apolipoproteins E (ApoE)IBA 10/2017 - 01/2013
2	IronIBA 01/2016 - 09/2011
2	Succinate Dehydrogenase (Fumarate Reductase)IBA 01/2016 - 12/2012
2	Focal Adhesion Protein-Tyrosine KinasesIBA 02/2015 - 05/2013
2	Insulin (Novolin)FDA Link 08/2014 - 12/2010
2	LipidsIBA 01/2013 - 11/2011
2	Glutamine (L-Glutamine)FDA Link 01/2013 - 11/2011
2	Tricarboxylic AcidsIBA 07/2012 - 01/2010
2	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2010 - 08/2009
2	DNA (Deoxyribonucleic Acid)IBA 06/2005 - 06/2002
1	Microphthalmia-Associated Transcription FactorIBA 04/2023
1	mithramycin AIBA 04/2023
1	glembatumumab vedotinIBA 04/2023
1	Immunoconjugates (Immunoconjugate)IBA 04/2023
1	8- (6- methoxypyridin- 3- yl)- 3- methyl- 1- (4- piperazin- 1- yl- 3- trifluoromethylphenyl)- 1,3- dihydroimidazo(4,5- c)quinolin- 2- oneIBA 04/2023
1	Stromal Interaction Molecule 1IBA 01/2023
1	Streptozocin (Streptozotocin)FDA Link 01/2023
1	CalciumIBA 01/2023
1	Mitochondrial DNA (mtDNA)IBA 01/2021
1	HexosaminesIBA 01/2020
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 01/2020
1	AsparagineIBA 01/2020
1	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2019
1	(5- (2,4- bis((3S)- 3- methylmorpholin- 4- yl)pyrido(2,3- d)pyrimidin- 7- yl)- 2- methoxyphenyl)methanolIBA 09/2019
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/2019
1	Dasatinib (BMS 354825)FDA Link 02/2018
1	p38 Mitogen-Activated Protein KinasesIBA 01/2018
1	Dichloroacetic AcidIBA 01/2018
1	Dietary PotassiumIBA 10/2017
1	PotassiumIBA 10/2017
1	oxidized low density lipoproteinIBA 06/2016
1	low density lipoprotein inhibitorIBA 06/2016
1	Succinic Acid (Succinate)IBA 01/2016
1	IsotopesIBA 01/2016
1	SulfurIBA 01/2016
1	Phosphotransferases (Kinase)IBA 02/2015
1	Cyclin EIBA 02/2015
1	Caspase 3 (Caspase-3)IBA 02/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2015
1	Proto-Oncogene Proteins c-etsIBA 08/2014
1	Cadherins (E-Cadherin)IBA 08/2014
1	FAK-related nonkinaseIBA 05/2013
1	RNA (Ribonucleic Acid)IBA 01/2013
1	NADP (NADPH)IBA 01/2013
1	Platelet-Derived Growth FactorIBA 11/2012
1	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 11/2012
1	tempolIBA 11/2012
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 11/2012
1	Oncogene Proteins (Oncogene Protein)IBA 11/2012
1	Citric Acid (Citrate)FDA LinkGeneric 11/2011
1	CarbonIBA 11/2011
1	Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA 11/2011
1	Acetyl Coenzyme A (Acetyl-CoA)IBA 11/2011
1	Iron-Regulatory Proteins (Iron-Responsive Element Binding Proteins)IBA 09/2011
1	Acetyl-CoA CarboxylaseIBA 09/2011
1	AMP-Activated Protein KinasesIBA 09/2011
1	Ribosomal Protein S6IBA 09/2011
1	Orexin ReceptorsIBA 04/2011
1	OrexinsIBA 04/2011
1	Bortezomib (Velcade)FDA Link 10/2010
1	Cisplatin (Platino)FDA LinkGeneric 10/2010

Therapy/Procedure

3	Therapeutics 04/2023 - 10/2010